The baby was referred from the Savelugu Hospital to the Northern Regional Hospital in Tamale but died shortly afterwards.
The two others are an 80-year old lady who died in May and a 24-year-old lady who died last week.
The Northern Regional Health Director, Dr John Eleazer, in a radio interview with Accra-based Citi FM said the region has a total case count of 52.
According to him, 32 persons have recovered from the disease, with 17 active cases being managed at home.
As at Tuesday, June 16, Ghana's total case count stood at 12,193 with 4,326 recoveries and 58 deaths.
The total number of active cases was 7,809.